Role of Oxidative Stress in Various Stages of Psoriasis     

Kadam DP  Suryakar AN  Ankush RD  Kadam CY  Deshpande KH 《Indian journal of clinical biochemistry : IJCB》2010,25(4):388-392

Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. Recently, it has been suggested that increased reactive oxygen species (ROS) production and compromised function of antioxidant system may be involved in the pathogenesis of this disease. In the present study, 90 psoriasis patients were selected. Disease severity was assessed by psoriasis area severity index score and grouped as mild, moderate and severe (each group consists of 30 subjects) and compared with 30 healthy controls. Serum levels of malondialdehyde, nitric oxide end products and the activities of antioxidant enzymes such as erythrocyte-superoxide dismutase, catalase and total antioxidant status were investigated in these groups/subjects. As compared to controls, we found severitywise significantly increased serum malondialdehyde, nitric oxide end products with decrease in erythrocyte-superoxide dismutase activity, catalase activity and total antioxidant status in patients with psoriasis suggesting worsening of the disease. It seems to be linked with the enhancement of Reactive Oxygen Species production and decreased antioxidant potential in psoriasis.  相似文献   

研究生学位论文引文分析系统的分析与设计     

刘暐  赵嵩正  殷茗 《情报科学》2006,24(8):1249-1252

本文提出了研究生学位论文引文分析系统的设计方案。在介绍了引文分析方法的基本理论的基础上，对研究生学位论文的引文分析系统的流程与功能进行了设计，并以24部博士学位论文作为数据源介绍了系统的具体应用，该系统对揭示研究生文献需求的规律和特点、提高馆藏文献采编质量具有实际意义。  相似文献   

供应链上信息流集成的实现和优化分析     

员巧云  刘斌  陈剑 《科学学与科学技术管理》2007,28(7):14-17

研究有效的供应链信息共享模式,寻求供应链信息流集成的实现途径和优化手段。通过网络数据结构建立信息流网络模型,并构建信息流集成块,求顶点间的最小路径以确定两两信息共享成本最小的信息流集成块,利用信息共享能力指标体系和信息共享度来测量和确定信息流集成中心,提出了优化供应链信息流集成的方法和途径。  相似文献   

同类产品(服务)竞争优势变动趋势——基于客户满意度的动态分析框架     

高江舟  李常洪 《科技与管理》2007,9(3):76-78

为了能更深入地考察同类产品（服务）在消费者市场中的长期稳定状态,采用独立增量过程——马尔可夫链,基于客户满意度建立动态优势测度分析模型,并结合算例加以分析。预测同类产品（服务）在消费市场中客户满意度的变化及长期稳定状态,使得企业能够掌握及预测本企业产品（服务）在提供同类产品的所有企业中客户满意度的竞争地位,为企业决策提供依据。  相似文献   

The impact of R&D spillovers on UK manufacturing TFP: A dynamic panel approach     

Dolores Añón Higón 《Research Policy》2007,36(7):964-979

One of the benefits claimed for investment in Research and Development (R&D) is that there is a spillover effect. Industries benefit from both their own R&D efforts as well as the efforts of other national and overseas industries. The present research presents new evidence on the long-term impact of R&D investment upon UK industry's productivity performance and on the nature of these “R&D spillovers”. The results suggest that R&D efforts from the industry itself and from other national industries have a positive impact on the industry's productivity but, interestingly, there is no gain from foreign R&D investment.  相似文献   

Effects of short-term hormone replacement on atherogenic indices in Indian postmenopausal women     

Sarika Arora  Anju Jain  R Chitra 《Indian journal of clinical biochemistry : IJCB》2006,21(1):41-47

Indian ethnicity by itself is a strong risk factor for development of CAD in Indian postmenopausal women due to lower HDL levels as compared to Whites and women of oriental origin. We evaluated and compared the short-term effects of menopause, estrogen replacement therapy and combined estrogen and progestin replacement therapy on various atherogenic indices. 40 postmenopausal women, both surgical and natural (20 each) were selected. 10 surgical postmenopausal women were given 0.625 mg conjugated estrogens daily for 6 months and 10 natural postmenopausal women were given 0.625 mg conjugated estrogen with 2.5 mg medroxyprogesterone acetate daily. 20 women were included in the control group and given placebo. Fasting venous blood samples were analyzed for extended lipid profile and calculated atherogenic indices before starting the therapy and after 1,3 and 6 months. LDL and Apolipoprotein B increased (p<0.05) and those of Apolipoprotein A1 and HDL decreased in the control groups. In both the study groups levels of serum cholesterol and LDL decreased (p<0.05) and those of HDL and Apolipoprotein A1 increased (p<0.01). LDL/HDL, Apo B/ApoA1, Total Cholesterol/HDL decreased significantly (p<0.05) in both the study groups compared to the control groups. The effect of estrogen alone was more significant as compared to combination therapy. Log Triglycerides (TG)/HDL ratio showed a decrease in women on estrogen alone but the difference was not significant. Our study confirms that short term HRT has a favorable effect on atherogenic indices in Indian postmenopausal women.  相似文献   

Application of Sigma Metrics for the Assessment of Quality Assurance in Clinical Biochemistry Laboratory in India: A Pilot Study     

Singh B  Goswami B  Gupta VK  Chawla R  Mallika V 《Indian journal of clinical biochemistry : IJCB》2011,26(2):131-135

Ensuring quality of laboratory services is the need of the hour in the field of health care. Keeping in mind the revolution ushered by six sigma concept in corporate world, health care sector may reap the benefits of the same. Six sigma provides a general methodology to describe performance on sigma scale. We aimed to gauge our laboratory performance by sigma metrics. Internal quality control (QC) data was analyzed retrospectively over a period of 6 months from July 2009 to December 2009. Laboratory mean, standard deviation and coefficient of variation were calculated for all the parameters. Sigma was calculated for both the levels of internal QC. Satisfactory sigma values (>6) were elicited for creatinine, triglycerides, SGOT, CPK-Total and Amylase. Blood urea performed poorly on the sigma scale with sigma <3. The findings of our exercise emphasize the need for detailed evaluation and adoption of ameliorative measures in order to effectuate six sigma standards for all the analytical processes.  相似文献   

产业创新复合系统构建与协同度分析——以信息通信产业为例     

董豪  曾剑秋  沈孟如 《科学学研究》2016,33(8):1152-1160

产业创新不仅要注重各子系统的创新能力提升,更要注重创新复合系统的整体协同效应。信息通信产业是推动国家经济转型,产业升级的基础性产业,以信息通信产业为例研究产业创新复合系统的协同发展,有助于提升信息通信产业创新能力并且促进其他产业的创新发展。论文以复杂系统理论为基础,构建了信息通信产业创新复合系统理论模型;基于信息通信产业2003-2013年的面板数据,运用复合系统协同度模型对信息通信产业创新复合系统进行实证分析。研究表明信息通信产业创新复合系统总体协同度不高,并且在2009-2010年出现震荡,主要原因是制度创新子系统的不协调以及创新环境子系统有序度长期处于较低水平,针对出现的问题提出相应的策略建议,最后说明了研究的不足之处及进一步研究方向。  相似文献   

素数在域Q(u~[1/(l~n)])上素理想分解     

薄丽玲  岳勤 《中国科学院研究生院学报》2006,(5)

设F=Q(u~[1/(l~n)]),其中l是奇素数.本文给出了奇素数p在整数环OF中的素理想分解形式.  相似文献   

1990～2012年北部湾经济区土地利用程度变化分析     

黄春芳  马文东  李鸿儒  莫正斌 《大众科技》2016,(7):38-40

通过对1990～2012年北部湾经济区土地利用结构的变化分析,运用土地利用程度指数模型以及土地利用程度变化模型统计了各地区土地利用程度的时空变化特征及其区域差异。结果表明,1990～2012年北部湾经济区土地利用程度大幅度提升,增加了43.22个百分点,但土地利用程度分布格局并未发生太大变化;土地利用程度变化量及其变化率均大于0,土地利用处于发展期;在自然条件的限制下,区域内部土地利用程度差异较大。  相似文献